{"id":1373459,"date":"2023-07-25T15:30:30","date_gmt":"2023-07-25T13:30:30","guid":{"rendered":"https:\/\/dev.dnaera.com\/cs\/?p=1373459"},"modified":"2023-08-15T15:56:56","modified_gmt":"2023-08-15T13:56:56","slug":"nemelanomova-rakovina-kuze-problemem-nemusi-byt-pouze-znamenka","status":"publish","type":"post","link":"https:\/\/dev.dnaera.com\/cs\/blog\/nemelanomova-rakovina-kuze-problemem-nemusi-byt-pouze-znamenka\/","title":{"rendered":"Nemelanomov\u00e1 rakovina k\u016f\u017ee \u2013 probl\u00e9mem nemus\u00ed b\u00fdt pouze znam\u00e9nka"},"content":{"rendered":"\n

K\u016f\u017ee p\u0159edstavuje \u00fa\u010dinnou bari\u00e9ru, kter\u00e1 n\u00e1s chr\u00e1n\u00ed p\u0159ed vlivy vn\u011bj\u0161\u00edho prost\u0159ed\u00ed, patogeny, chladem nebo teplem. D\u00edky velk\u00e9mu mno\u017estv\u00ed citliv\u00fdch bun\u011bk v k\u016f\u017ei c\u00edt\u00edme dotek, bolest nebo tlak. P\u016fsoben\u00edm slune\u010dn\u00edho z\u00e1\u0159en\u00ed se v k\u016f\u017ei tvo\u0159\u00ed vitam\u00edn D, kter\u00fd m\u00e1 v t\u011ble n\u011bkolik nezastupiteln\u00fdch funkc\u00ed. \u00da\u010dinek UV z\u00e1\u0159en\u00ed na na\u0161i k\u016f\u017ei je tedy pot\u0159ebn\u00fd, av\u0161ak jeho nadm\u011brn\u00e9 mno\u017estv\u00ed m\u016f\u017ee p\u0159isp\u011bt ke vzniku rakoviny k\u016f\u017ee. P\u016fsoben\u00edm UV z\u00e1\u0159en\u00ed toti\u017e doch\u00e1z\u00ed k po\u0161kozen\u00ed DNA neboli mutac\u00edm. Pr\u00e1v\u011b tyto zm\u011bny vedou ke vzniku n\u00e1dorov\u00fdch bun\u011bk, kter\u00e9 se z k\u016f\u017ee mohou \u0161\u00ed\u0159it tak\u00e9 do dal\u0161\u00edch \u010d\u00e1st\u00ed t\u011bla. Ke v\u010dasn\u00e9 diagnostice m\u016f\u017ee p\u0159isp\u011bt i znalost genetick\u00fdch predispozic. Na\u0161i st\u00e1vaj\u00edc\u00ed z\u00e1kazn\u00edci si ve sv\u00fdch v\u00fdsledc\u00edch najdou zdarma nov\u00fd v\u00fdsledek za\u0159azen\u00fd v kategorii Zdrav\u00ed. <\/em><\/p>\n\n\n\n

Existuje melanomov\u00e1 a nemelanomov\u00e1 rakovina k\u016f\u017ee<\/strong><\/h2>\n\n\n\n

Nejz\u00e1ke\u0159n\u011bj\u0161\u00ed formu rakoviny k\u016f\u017ee p\u0159edstavuje melanom, kter\u00fd postihuje bu\u0148ky produkuj\u00edc\u00ed ko\u017en\u00ed barvivo \u2013 melanocyty. Ten v\u0161ak tvo\u0159\u00ed p\u0159ibli\u017en\u011b jen 1 % p\u0159\u00edpad\u016f rakoviny k\u016f\u017ee. V\u00edce o melanomu si m\u016f\u017eete p\u0159e\u010d\u00edst v na\u0161em<\/a> blogu. A\u017e 99 % p\u0159\u00edpad\u016f rakoviny k\u016f\u017ee tvo\u0159\u00ed onemocn\u011bn\u00ed se spole\u010dn\u00fdm n\u00e1zvem nemelanomov\u00e1 rakovina k\u016f\u017ee. <\/p>\n\n\n\n

Rakovina k\u016f\u017ee se nemus\u00ed vyskytovat pouze ve form\u011b znam\u00e9nek.<\/strong><\/h2>\n\n\n\n

Znam\u00e9nka obsahuj\u00ed velk\u00e9 mno\u017estv\u00ed melanocyt\u016f, a proto p\u0159edstavuj\u00ed rizikov\u00e1 m\u00edsta pro vznik rakoviny k\u016f\u017ee. Nemelanomov\u00e1 rakovina k\u016f\u017ee se v\u0161ak vyskytuje v\u011bt\u0161inou pr\u00e1v\u011b mimo n\u011b a postihuje hlavn\u011b bu\u0148ky poko\u017eky (keratinocyty) a baz\u00e1ln\u00ed bu\u0148ky, ze kter\u00fdch se keratinocyty tvo\u0159\u00ed. Bazocelul\u00e1rn\u00ed karcinom vypad\u00e1 typicky jako perle\u0165ov\u00fd nebo voskov\u00fd hrbolek na k\u016f\u017ei s \u010dasto viditeln\u00fdmi krevn\u00edmi c\u00e9vami. Spinocelul\u00e1rn\u00ed karcinom v\u011bt\u0161inou vypad\u00e1 jako \u0161upinat\u00fd, r\u016f\u017eov\u00fd \u010di \u010derven\u00fd hrbolek, p\u0159\u00edpadn\u011b jako ztvrdl\u00e1 skvrna na k\u016f\u017ei. <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Hlavn\u00edm rizikov\u00fdm faktorem pro vznik rakoviny k\u016f\u017ee je UVB z\u00e1\u0159en\u00ed<\/strong><\/h2>\n\n\n\n

UVB z\u00e1\u0159en\u00ed je typ slune\u010dn\u00edho UV z\u00e1\u0159en\u00ed, kter\u00e9 je zodpov\u011bdn\u00e9 za sp\u00e1len\u00ed k\u016f\u017ee a s n\u00edm souvisej\u00edc\u00ed zm\u011bny v DNA. \u00da\u010dinnou ochranou je vyh\u00fdb\u00e1n\u00ed se slune\u010dn\u00edm paprsk\u016fm (zejm\u00e9na mezi 10:00 a 16:00 hodinou), no\u0161en\u00ed ochrann\u00e9ho oble\u010den\u00ed, pokr\u00fdvky hlavy a p\u0159edev\u0161\u00edm spr\u00e1vn\u00e1 aplikace opalovac\u00edho kr\u00e9mu s ochrann\u00fdm faktorem minim\u00e1ln\u011b 30. Do rizikov\u00e9 skupiny pat\u0159\u00ed zejm\u00e9na lid\u00e9 se sv\u011btl\u00fdm typem pleti, \u010d\u00e1st\u00ed n\u00e1v\u0161t\u011bvn\u00edci sol\u00e1ri\u00ed, ku\u0159\u00e1ci \u010di lid\u00e9 s oslabenou imunitou. Obzvl\u00e1\u0161\u0165 d\u016fle\u017eit\u00e9 je chr\u00e1nit p\u0159ed sp\u00e1len\u00edm mal\u00e9 d\u011bti, proto\u017ee ka\u017ed\u00e9 sp\u00e1len\u00ed b\u011bhem \u017eivota zvy\u0161uje riziko. <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Vliv maj\u00ed i na\u0161e geny<\/strong><\/h2>\n\n\n\n

U n\u011bkter\u00fdch lid\u00ed prob\u00edhaj\u00ed zm\u011bny na k\u016f\u017ei, kter\u00e9 mohou v\u00e9st ke vzniku nemelanomov\u00e9 rakoviny k\u016f\u017ee, o n\u011bco snadn\u011bji ne\u017e u jin\u00fdch. Tyto geny se pod\u00edlej\u00ed na tvorb\u011b melaninu, kter\u00fd chr\u00e1n\u00ed poko\u017eku p\u0159ed UV z\u00e1\u0159en\u00edm, zabra\u0148uj\u00ed nekontrolovateln\u00e9mu d\u011blen\u00ed bun\u011bk a pom\u00e1haj\u00ed udr\u017eovat stabilitu chromozom\u016f v j\u00e1dru bu\u0148ky. P\u0159\u00edtomnost ur\u010dit\u00fdch genetick\u00fdch variant v DNA v\u00e1s tedy m\u016f\u017ee \u010dinit n\u00e1chyln\u011bj\u0161\u00edmi k rozvoji nemelanomov\u00e9 rakoviny k\u016f\u017ee. <\/p>\n\n\n\n

Nov\u00fd v\u00fdsledek anal\u00fdzy<\/strong><\/h2>\n\n\n\n

Informace o sv\u00e9m genetick\u00e9m riziku pro rozvoj tohoto onemocn\u011bn\u00ed a dal\u0161\u00ed poznatky t\u00fdkaj\u00edc\u00ed se nemelanomov\u00e9 rakoviny k\u016f\u017ee m\u00e1te uvedeny ve sv\u00fdch v\u00fdsledc\u00edch. P\u0159ihlaste se ke sv\u00e9mu \u00fa\u010dtu<\/a><\/strong> a dodr\u017eujte z\u00e1kladn\u00ed preventivn\u00ed opat\u0159en\u00ed. Nov\u00fd v\u00fdsledek z\u00edskaj\u00ed takt\u00e9\u017e v\u0161ichni budouc\u00ed z\u00e1kazn\u00edci, kte\u0159\u00ed si objednaj\u00ed DNA Complex test<\/a> nebo DNA Health test<\/a>. V r\u00e1mci roz\u0161\u00ed\u0159en\u00ed jej mohou p\u0159\u00edmo ve sv\u00fdch v\u00fdsledc\u00edch bez pot\u0159eby opakov\u00e1n\u00ed odb\u011bru vzorku z\u00edskat i v\u0161ichni ostatn\u00ed z\u00e1kazn\u00edci. <\/p>\n\n\n\n

Zdroje:<\/strong><\/p>\n\n\n\n

    \n
  1. Gordon, R. (2013, August). Skin cancer: an overview of epidemiology and risk factors. In Seminars in oncology nursing (Vol. 29, No. 3, pp. 160-169). WB Saunders.<\/li>\n\n\n\n
  2. https:\/\/www.nhs.uk\/conditions\/non-melanoma-skin-cancer\/<\/li>\n\n\n\n
  3. https:\/\/www.cancer.net\/cancer-types\/skin-cancer-non-melanoma\/risk-factors-and-prevention<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    K\u016f\u017ee p\u0159edstavuje \u00fa\u010dinnou bari\u00e9ru, kter\u00e1 n\u00e1s chr\u00e1n\u00ed p\u0159ed vlivy vn\u011bj\u0161\u00edho prost\u0159ed\u00ed, patogeny, chladem nebo teplem. D\u00edky velk\u00e9mu mno\u017estv\u00ed citliv\u00fdch bun\u011bk v k\u016f\u017ei c\u00edt\u00edme dotek, bolest nebo tlak. P\u016fsoben\u00edm slune\u010dn\u00edho z\u00e1\u0159en\u00ed se v k\u016f\u017ei tvo\u0159\u00ed vitam\u00edn D, kter\u00fd m\u00e1 v t\u011ble n\u011bkolik nezastupiteln\u00fdch funkc\u00ed. \u00da\u010dinek UV z\u00e1\u0159en\u00ed na na\u0161i k\u016f\u017ei je tedy pot\u0159ebn\u00fd, av\u0161ak jeho nadm\u011brn\u00e9 […]<\/p>\n","protected":false},"author":6,"featured_media":1373462,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1373459","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test"],"acf":[],"views":697,"_links":{"self":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1373459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/comments?post=1373459"}],"version-history":[{"count":5,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1373459\/revisions"}],"predecessor-version":[{"id":1373586,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1373459\/revisions\/1373586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/media\/1373462"}],"wp:attachment":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/media?parent=1373459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/categories?post=1373459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/tags?post=1373459"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1373459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}