{"id":1372574,"date":"2023-03-14T12:15:49","date_gmt":"2023-03-14T11:15:49","guid":{"rendered":"https:\/\/dev.dnaera.com\/cs\/?p=1372574"},"modified":"2023-03-29T10:09:09","modified_gmt":"2023-03-29T08:09:09","slug":"mutyh","status":"publish","type":"post","link":"https:\/\/dev.dnaera.com\/cs\/blog\/mutyh\/","title":{"rendered":"Geny ovliv\u0148uj\u00ed i vznik polyp\u016f zp\u016fsobuj\u00edc\u00edch n\u00e1dory\u00a0"},"content":{"rendered":"\n

Na\u0161i z\u00e1kazn\u00edci ve sv\u00fdch v\u00fdsledc\u00edch najdou novou predispozici, kter\u00e1 souvis\u00ed s genetick\u00fdm onemocn\u011bn\u00edm za\u0159azen\u00fdm v kategorii Status p\u0159ena\u0161e\u010de. MUTYH asociovan\u00e1 polyp\u00f3za, zkr\u00e1cen\u011b MAP, je geneticky podm\u00edn\u011bn\u00e9 onemocn\u011bn\u00ed projevuj\u00edc\u00ed se a\u017e v dosp\u011blosti. Z v\u00fdsledku anal\u00fdzy DNA m\u016f\u017eete zjistit, zda jste p\u0159ena\u0161e\u010dem onemocn\u011bn\u00ed a zda u v\u00e1s samotn\u00fdch existuje vy\u0161\u0161\u00ed riziko. Pr\u00e1v\u011b proto je velkou v\u00fdhodou zn\u00e1t svoji predispozici je\u0161t\u011b p\u0159ed n\u00e1stupem prvn\u00edch p\u0159\u00edznak\u016f.<\/em><\/p>\n\n\n\n

D\u016fle\u017eitost prevence kolorekt\u00e1ln\u00edho karcinomu<\/h2>\n\n\n\n

Karcinom st\u0159eva a kone\u010dn\u00edku (kolorekt\u00e1ln\u00ed karcinom) u n\u00e1s p\u0159edstavuje jedno z nej\u010dast\u011bj\u0161\u00edch onkologick\u00fdch onemocn\u011bn\u00ed. P\u0159i rozvoji n\u00e1doru hraj\u00ed d\u016fle\u017eitou roli zm\u011bny v DNA. K t\u011bmto zm\u011bn\u00e1m m\u016f\u017ee doch\u00e1zet i \u00faplnou n\u00e1hodou, a proto je pro v\u010dasn\u00e9 odhalen\u00ed n\u00e1doru kl\u00ed\u010dov\u00e1 sekund\u00e1rn\u00ed prevence v podob\u011b preventivn\u00edch l\u00e9ka\u0159sk\u00fdch prohl\u00eddek. Existuj\u00ed ale mutace, kter\u00e9 n\u011bkolikan\u00e1sobn\u011b zvy\u0161uj\u00ed riziko vzniku kolorekt\u00e1ln\u00edho karcinomu a jsou d\u011bdi\u010dn\u00e9. <\/p>\n\n\n\n

Pokud pacienti nepodstoup\u00ed l\u00e9\u010dbu, je riziko a\u017e o 90 % vy\u0161\u0161\u00ed<\/h2>\n\n\n\n

Jednou z takov\u00fdch d\u011bdi\u010dn\u00fdch forem je MUTYH asociovan\u00e1 polyp\u00f3za (MAP), p\u0159i kter\u00e9 doch\u00e1z\u00ed ke zv\u00fd\u0161en\u00e9 tvorb\u011b polyp\u016f v tlust\u00e9m st\u0159ev\u011b. Tyto abnorm\u00e1ln\u00ed v\u00fdr\u016fstky jsou zpo\u010d\u00e1tku ne\u0161kodn\u00e9; n\u011bkter\u00e9 polypy se v\u0161ak mohou \u010dasem zm\u011bnit ve zhoubn\u00e9, \u010d\u00edm\u017e doch\u00e1z\u00ed ke vzniku n\u00e1doru.<\/p>\n\n\n\n

Po 60. roce \u017eivota se riziko vzniku kolorekt\u00e1ln\u00edho karcinomu u osob s MAP zvy\u0161uje a\u017e o 43\u201363 %. Pro porovn\u00e1n\u00ed: riziko u b\u011b\u017en\u00e9 populace \u010din\u00ed 5,5 %. Diagn\u00f3za MAP z\u00e1rove\u0148 vede ke zv\u00fd\u0161en\u00e9mu riziku rakoviny vaje\u010dn\u00edk\u016f, mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e, dvan\u00e1ctern\u00edku a \u0161t\u00edtn\u00e9 \u017el\u00e1zy.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Jak se d\u011bd\u00ed MAP? <\/h2>\n\n\n\n

MAP se d\u011bd\u00ed autozom\u00e1ln\u011b recesivn\u00edm zp\u016fsobem. To znamen\u00e1, \u017ee na to, aby se onemocn\u011bn\u00ed projevilo, je pot\u0159eba od obou dvou rodi\u010d\u016f zd\u011bdit po\u0161kozenou kopii ur\u010dit\u00e9ho genu.  V\u00fdjime\u010dn\u011b mohou tyto mutace vznikat i tzv. de novo b\u011bhem \u017eivota. V p\u0159\u00edpad\u011b MAP je t\u00edmto genem MUTYH. Tento gen se pod\u00edl\u00ed na oprav\u011b po\u0161kozen\u00ed DNA, ke kter\u00fdm do\u0161lo \u010dinnost\u00ed voln\u00fdch radik\u00e1l\u016f. Pokud je dan\u00fd gen nefunk\u010dn\u00ed a po\u0161kozen\u00ed DNA nejsou opravena, doch\u00e1z\u00ed ke vzniku mutac\u00ed.<\/p>\n\n\n\n

Jeden a\u017e dva lid\u00e9 ze sta<\/h2>\n\n\n\n

Statistiky uk\u00e1zaly, \u017ee 1 a\u017e 2 osoby ze 100 nesou ve sv\u00e9 DNA jednu po\u0161kozenou kopii genu MUTYH. V takov\u00e9mto p\u0159\u00edpad\u011b jsou pouze p\u0159ena\u0161e\u010di onemocn\u011bn\u00ed, p\u0159i\u010dem\u017e studie prok\u00e1zaly, \u017ee u nich riziko rozvoje kolorekt\u00e1ln\u00edho karcinomu nen\u00ed vy\u0161\u0161\u00ed ne\u017e u osob, kter\u00e9 maj\u00ed dv\u011b standardn\u00ed kopie genu MUTYH. <\/p>\n\n\n\n

Znalost poskytuje jedine\u010dnou formu prevence<\/h2>\n\n\n\n

Informace, \u017ee jste p\u0159ena\u0161e\u010dem, je d\u016fle\u017eit\u00e1 pro v\u0161echny rodi\u010de. V p\u0159\u00edpad\u011b, \u017ee je toto onemocn\u011bn\u00ed p\u0159en\u00e1\u0161eno ob\u011bma rodi\u010di, existuje 25% \u0161ance, \u017ee jejich d\u00edt\u011b zd\u011bd\u00ed od obou pr\u00e1v\u011b po\u0161kozenou kopii genu. V p\u0159\u00edpad\u011b, \u017ee jste p\u0159ena\u0161e\u010dem MAP, doporu\u010dujeme v\u00e1m nechat otestovat i partnera nebo partnerku. Pokud onemocn\u011bn\u00ed p\u0159en\u00e1\u0161\u00edte oba, je v dal\u0161\u00edm kroku vhodn\u00e9 nechat otestovat d\u011bti. Znalost t\u00e9to informace jim poskytuje jedine\u010dnou formu prevence, kter\u00e1 dok\u00e1\u017ee identifikovat p\u0159\u00edpadn\u00fd probl\u00e9m d\u0159\u00edve ne\u017e jak\u00e9koliv b\u011b\u017en\u00e9 preventivn\u00ed vy\u0161et\u0159en\u00ed.<\/strong><\/p>\n\n\n\n

Nov\u00e1 predispozice nyn\u00ed ve va\u0161\u00ed anal\u00fdze<\/h2>\n\n\n\n

P\u0159ihlaste se do sv\u00e9ho \u00fa\u010dtu<\/a><\/strong> ve webov\u00e9 aplikaci a pod\u00edvejte se na sv\u016fj v\u00fdsledek. Nov\u00e1 predispozice p\u0159ibyla automaticky zdarma v\u0161em na\u0161im sou\u010dasn\u00fdm z\u00e1kazn\u00edk\u016fm. Budouc\u00ed z\u00e1kazn\u00edci najdou tuto predispozici v DNA Complex testu<\/a> a DNA Health testu<\/a>. Poznat svoje geny m\u00e1 smysl v ka\u017ed\u00e9m v\u011bku. \u010c\u00edm d\u0159\u00edve, t\u00edm l\u00e9pe. Za\u010dn\u011bte svou DNA objevovat i vy. <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Zdroje:<\/strong><\/p>\n\n\n\n

    \n
  1. Curia MC, Catalano T, Aceto GM. MUTYH: Not just polyposis. World J Clin Oncol. 2020.<\/li>\n\n\n\n
  2. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK107219\/<\/a><\/li>\n\n\n\n
  3. https:\/\/my.clevelandclinic.org\/health\/diseases\/17254-myh-associated-polyposis<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Na\u0161i z\u00e1kazn\u00edci ve sv\u00fdch v\u00fdsledc\u00edch najdou novou predispozici, kter\u00e1 souvis\u00ed s genetick\u00fdm onemocn\u011bn\u00edm za\u0159azen\u00fdm v kategorii Status p\u0159ena\u0161e\u010de. MUTYH asociovan\u00e1 polyp\u00f3za, zkr\u00e1cen\u011b MAP, je geneticky podm\u00edn\u011bn\u00e9 onemocn\u011bn\u00ed projevuj\u00edc\u00ed se a\u017e v dosp\u011blosti. Z v\u00fdsledku anal\u00fdzy DNA m\u016f\u017eete zjistit, zda jste p\u0159ena\u0161e\u010dem onemocn\u011bn\u00ed a zda u v\u00e1s samotn\u00fdch existuje vy\u0161\u0161\u00ed riziko. Pr\u00e1v\u011b proto je velkou v\u00fdhodou […]<\/p>\n","protected":false},"author":6,"featured_media":1372575,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1372574","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test"],"acf":[],"views":303,"_links":{"self":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1372574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/comments?post=1372574"}],"version-history":[{"count":5,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1372574\/revisions"}],"predecessor-version":[{"id":1372595,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/posts\/1372574\/revisions\/1372595"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/media\/1372575"}],"wp:attachment":[{"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/media?parent=1372574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/categories?post=1372574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/tags?post=1372574"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dev.dnaera.com\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1372574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}